Peptide Therapy
If you’ve been searching for ways to restore your youthful look and vigor, you may have heard of growth hormone therapy or peptide therapy. Peptides, a natural form of growth hormone, stimulates the pituitary gland to produce more human growth hormone (HGH), so your body can continue to flourish and feel youthful.
As we age, our growth hormone naturally declines and we slowly start to age. HGH is critical when you are a child and helps us to grow tall and feel strong. As a child we also have beautiful hair and our nails constantly need to be trimmed. However, when you are an adult, your body naturally declines or stops producing as much HGH. Without HGH, we experience brittle hair and dry skin, loss of muscle mass, lethargy, poor cognitive function, and slower recovery from injuries, just to name a few.
Types of Peptide Therapy:
Peptide Therapy: Ipamorelin
What is Ipamorelin Acetate?
Ipamorelin Acetate is a Growth Hormone Releasing Peptide (GHRP) that stimulates the pituitary gland within the body to release natural growth hormone (GH). Ipamorelin Acetate is a pentapeptide composed of five amino acids and has a biological half-life of 2 hours after administration. It is widely known for being able to suppress somatostatin or growth inhibiting hormone.
As we age, our hormone levels fluctuate interfering with patient’s overall quality of life. Imbalances can result in loss of energy, increased irritability, sleeplessness, memory problems, and low sex drive. Utilizing peptide therapy separately or in conjunction with hormone replacement may restore optimal hormone levels in your patients. Studies suggest that Ipamorelin Acetate did not affect FSH, LH, Prolactin, or TSH levels. Furthermore, Ipamorelin did not seem to have an impact on cortisol and ACTH levels during GHRH stimulation.
Patient Benefits Over Time May Include:
- Aid in the body’s ability to burn fat
- Helps improve lean muscle mass
- Supports immune system
- Improved sex drive
- Strengthened cardiovascular system
- Improved quality of sleep
- Improved energy and endurance
- Supports bone density
- Improved skin firmness and moisture retention
- Improved cognition and memory
Peptide Therapy: CJC 1295
A synthetically produced peptide, CJC 1295 was originally made to treat diseases, but has been discovered to have performance-enhancing effects that appeal to athletes. The peptide works by increasing protein synthesis and insulin-like growth factor levels. This process enables muscle tissue to grow, thereby increasing muscle mass and function.
CJC-1295 can help individuals over the age of 30 to have more energy, a faster metabolism, and stay in better shape as you age. It is often used in combination with Ipamorelin. CJC-1295 and Ipamorelin are typically combined in therapy because they are known to work well together. CJC-1295 takes anywhere from 1-4 hours to reach peak serum in the blood, while Ipamorelin works much quicker. Ipamorelin is cleared from the body more rapidly as its half-life is about 2 hours. The combination of both peptides ensures a rapid onset with Ipamorelin and lasting effects with CJC-1295. These 2 peptides are incredibly specific at increasing growth hormone levels when compared to other peptides. Other peptide can increase levels of cortisol (as seen with stress, can increase hunger) but neither Ipamorelin nor CJC-1295 influence other hormones which is a great advantage.
CJC 1295 is a subcutaneous injection best used right before bed and most often in combination with another peptide. Some benefits of CJC 1295 include:
- Increased bone density
- Increase in muscle mass
- Strengthens the cardiovascular system
- Increased sex drive
- Improved recovery and repair from injuries
- Strengthens immune system
- More muscle mass revs up metabolic rate = less body fat
- Improves cognition and mental clarity
- Improves insulin sensitivity thus reducing the body’s triglycerides and body fat.
Peptide Therapy: Sermorelin
Sermorelin is a peptide that helps your pituitary gland produce more HGH naturally. These injections can reverse or stop many issues that develop due to HGH deficiency. Sermorelin Acetate is a growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to produce and release HGH. Sermorelin Acetate mimics the effects of HGH, but tells the pituitary gland in the body to produce HGH naturally. This means that Sermorelin will have similar effects of HGH, but without the side effects and cost.
Sermorelin therapy benefits include:
- Increase in muscle mass development after exercise, faster recovery from strenuous exercise, increased energy and endurance, better strength, and joint and muscle pain relief for patients with arthritis and chronic pain
- Improved cognitive function (better mental clarity), better vision, better bone health, enhanced immune system, stronger heart, and improved cardiovascular function
- Fat reduction (especially abdominal fat), restored vitality, youthful and glowing skin, thicker hair and nails, and an improved sense of well-being
- Accelerated healing from wounds or surgery, increase in libido and better sexual performance, improved sleep quality, and better mood
Sermorelin therapy is typically administered subcutaneously right before bed. Results are typically seen 90 to 180 days after starting the Sermorelin Acetate protocol. After six months you should have seen or felt most of the benefits listed above. The first week of your Sermorelin protocol you should notice an increased quality of sleep. You will wake up feeling well rested, and may notice your afternoon crash is gone. Many patients report that they are not waking up in the middle of the night anymore. The next benefit that patients report comes at about two weeks, and is quicker recovery from workouts. You should feel less sore the day after working out and can extend your workouts in the gym because you are sleeping better and have more energy.
Within a month you’ll notice more mental clarity and less fatigue. Patients state that they feel more focused and have less brain fog. As time goes on your body will become leaner and you will notice your percentage of body fat dropping. You will be stronger in the weight room and have more cardiovascular endurance for physical activities. Other benefits seen along the way include improved skin tone and elasticity, making you appear younger and healthier.
Peptide Therapy: AOD 9604
Peptide AOD 9604, or commonly known as the fat-burning peptide has a natural ability to burn fat and help your body increase its weight loss. AOD injections help stimulate the pituitary gland without having harmful effects on your blood sugar, like some obesity medications can.
AOD 9604 can:
- Speed up the fat-burning process
- Perk up anabolism (building muscle)
- And lessen any catabolic effects (breaking down muscle)
- Regulate the body’s metabolism
- Stimulate the body’s metabolism natural fat-burning process
- Triggers release of fat from obese fat cells
- And decreases the growth of new fat that surrounds the fat cells, which helps the body gain more significant weight loss.
Peptide AOD 9604 has also been seen to help bone and cartilage repair, osteoarthritis, and even hypercholesterolemia. AOD 9604’s strong fat burning capacity doesn’t create any overheating, and even stimulates lipolysis (which is referred to as the breakdown or the destruction of body fat). It’s thermogenetic effects don’t even increase appetite, which is a huge plus.
The research hypothesis was proven in animals since the peptide had a significant impact on fat loss. AOD 9604 is known to have an excellent safety profile with the effects seen after only 12 weeks.
Peptide Therapy: BPC-157
What is BPC-157?
BPC-157 is a pentadecapeptide made up of 15 amino acids. It is a partial sequence of the body protection compound (BPC) derived from human gastric juice. Experiments have shown that it heightens the healing of many different types of tissues, including: tendon, muscle, nervous system, and is superior at healing damaged ligaments.
Patients who suffer from discomfort due to sprains, tears, and tissue damage may benefit from treatment with this peptide as it can increase blood flow back to the injured sites. BPC-157 may protect organs, prevent stomach ulcers, and heal skin burns.
Patient Benefits Over Time May Include:
- Accelerated wound healing
- Decreases inflammation
- Increased fibroblast
- Nitric oxide improvement
- Improves digestive function
- Enhanced vascular expression of VEGFR2
Peptide Therapy: PT-141
What is PT-141?
PT-141 was developed from the peptide Melanotan 2, which is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis that is known as alpha- Melanocyte stimulating hormone. PT-141 has been shown in studies to provide libido-enhancing effects by activating the melanocortin receptors MC1R and MC4R, without tanning the skin.
PT-141 is a potential remedy for the treatment of female sexual dysfunction and male erectile dysfunction. Studies have shown that PT-141 does not act on the vascular system, but may increase sexual desire through the nervous system.
Peptide Therapy: Semaglutide
What is Semaglutide?
Semaglutide is a glucagon-like peptide (GLP-1) analog. GLP-1 is a hormone produced in the small intestine that stimulates insulin secretion and inhibits glucagon secretion, thereby lowering blood sugar. Studies show that semaglutide reduces appetite, improves control of eating, and reduces food cravings in addition to improving glycemic control.
Why Semaglutide?
Struggling to lose weight? Excess weight is largely a result of eating habits but with busy lifestyles, everyday stress and modern food supply; not to mention hormones and genetics, it seems we are set up to fail. Semaglutide helps control appetite and cravings, setting your patient up for success.
Benefits may include:
- Weight Loss
- Feel Full Faster
- Slower Digestion Through Stomach
- Better Sleep Patterns
- Lowers Leptin Levels
- Diminish Hunger and Cravings
- Appetite Suppression
Expected results:
- Anecdotally, this peptide has been described by doctors as twice as effective as any prescription weight loss products on the market today, likening it to the equivalent of having gastric bypass surgery.
- Semaglutide trial results showed overweight or obese adults receiving weekly semaglutide had a mean weight loss of 14.9% at 68 weeks. In this same study, nearly 70% of participants were able to achieve a 10% weight loss threshold by taking semaglutide. And 32% of participants lost at least 20% of their initial weight.
Peptides are a string of amino acids or the “building blocks of protein.” Peptides are now the number one method for Anti-aging and wellness because they occur naturally within the body allowing them to be effective with very few side effects. As we age, our levels of essential amino acids and growth hormone start to decline causing multiple deficiencies. Peptides work to stimulate your body’s natural production of growth hormone. They have the potential to rewrite bodily chemistry relationships to help with hormone balance. This newly emerging science has the capability of slowing down the aging process, preventing illness, and enhancing peak performance.
Peptides may:
- Help improve our immune system
- Help us look and feel younger
- Improve workout recovery time
- Boost our libido
- Protect our DNA
- Help us lose body fat
- Reduce inflammation
- Sleep deeper
- Help our brains become sharper
- Promote slow wave sleep
- Improve memory retention
- Stimulate muscle growth
- Aid in fat loss and lean muscle
Growth hormone is important for growth and development until around 18-20 years of age. After that, it is needed as an adult for cellular repair and healing. As we age, our body begins to produce less growth hormone and thus lowers the ability to repair cell damage, which ultimately contributes to aging.
In a 1990 study published in the New England Journal of Medicine, Dr. Daniel Rudman noted that higher levels of human growth hormone (HGH) in men ranging in age from 61 to 81 conferred significant benefits and slowed the aging process.
Peptide use leads to the preservation of youthful anatomy and physiology without the possible harmful side effects associated with HGH administration. Also, law prohibits off-label use of HGH. The function of natural peptides is to stimulate the pituitary function, and produce more of your natural growth hormone. This increases the safety and minimizes the side effects. Another distinct advantage is cost. Typically, HGH can run $1000/month for treatment; peptides are a much more cost effective option with 3 months costing less than one month of treatment with HGH.
As of 2018, there are 60 peptide drugs that have been approved in the United States, Europe, and Japan. Over 150 are in active clinical development. 260 have been tested in human clinical trials (Lau J and Dunn M – Biorganic + Medical Chemistry 26-2018). As the science evolves, Biosymmetry plans to evolve as well.
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